In the lung, the airway epithelium produces secreted and tethered mucin biopolymers to form a mucus hydrogel layer and a surface-attached polymer brush layer. These layers work in concert to facilitate the cilia-mediated transport of mucus for the capture and clearance of inhaled materials to prevent lung damage. The mechanisms by which mucin biopolymers protect the lung from injury have been an intense area of study in airway biology for the past several decades. In this feature article, we will discuss how airway mucins achieve these protective barrier functions. We will present the key findings, rooted in polymer and surface science, that have aided in understanding mucin barrier function. In addition, we will describe how this work may influence the design of nanoparticles to overcome the mucus barrier to effective drug delivery.