Molecular dynamics (MD) simulation of an electrowetted nanodroplet is performed to understand the fundamental origin of the involved parameters resulted from the molecular movement in the vicinity of the three-phase contact line (TPCL). During the spreading of the droplet, contact line friction (CLF) force is found to be the controlling one among all other resistive forces. Being molecular in nature, MD study is required to unveil the CLF, which is manifested by the TPCL friction coefficient zeta. The combined effect of temperature, electric field, and surface wettability, manifested by the solid-liquid Lennard-Jones interaction parameter, is studied to explore the droplet spreading. The entire droplet wetting dynamics is divided into two different regimes, namely, spreading regime and equilibrium regime. The molecular frequency during the TPCL movement in the equilibrium regime is affected by the presence of any external perturbation and results in an alteration of zeta. The predetermined knowledge of the alteration of CLF due to the coupling effect of electric field and temperature will have a potential application towards designing electric field-inspired droplet movement devices.