The present study was proposed to clear toxic heavy metal cadmium using a novel hybrid material of chitosan oligosaccharide-g-glycidyl methacrylate/polypropylene glycol-glutaraldehyde blend. The blend was physicochemically characterized by FTIR, XRD, and SEM analysis. The sorption capacity was brought under batch mode to suit the optimal parameters, viz. initial concentration, adsorbent dose, pH, and agitation time, which influence the sorption. Experimental data were analyzed by Langmuir and Freundlich adsorption isotherms. The isotherm study revealed that the equilibrium adsorption is well fitted to the Freundlich isotherm. The kinetic studies showed that the adsorption process follows pseudo-second-order kinetics. The adsorbed sample was characterized by SEM-EDAX and FTIR analysis, which confirmed that adsorption took place effectively. The metal-loaded sorbent was taken for desorption studies revealed that 0.1 M HCl was the best eluent for desorption of cadmium metal ions in the desorption studies. The prepared blend is active against both the selected bacterial and fungal species, and hence, it can be considered as good antimicrobial agents, and it will effectively kills the microbes. From the results, it was concluded that COS-g-GMA/PPG-Glu is an excellent material as a biosorbent for removal Cd(II) ions from aqueous solution as well as good antimicrobial activity.