With the development of urbanization in China, the problem of urban public safety is becoming increasingly prominent. A scientific regional risk assessment of urban public safety can provide important support for risk warning and management systems. This study aims to introduce a comprehensive method to assess and manage regional risk factors of urban public safety. Taking regional risk assessment of urban public safety as the research object, and focusing on multiple sources of risk such as industry, infrastructure, traffic, and public places, this study provides a comprehensive and systematic classification of risks and identifies the characteristics of the various risk agents. The urban region is divided into three units: an industrial risk unit, an urban population-intensive unit, and an urban communal facilities unit. Then, a multi-agent index system for regional risk assessment in relation to urban public safety is established. Using the analytic hierarchy process, the entropy weight method, and multiple connection numbers, both static and dynamic analyses of regional risks in relation to urban public safety are undertaken and the regional risks in relation to urban public safety are predicted. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.