The present study shows the results of an experimental survey conducted over 34 months on 76 full-scale Wastewater Treatment Plants located in central Italy with the aim to determine the influent and effluent concentrations of 13 Organic Micropollutants belonging to the class of illicit drugs, pharmaceuticals and steroids. The survey focused on a large set of plants differing for the main characteristics (e.g. treatment capacity, type of lay-out). Based on the values measured in the influent and effluent, removal efficiency of each contaminant in each plant was also determined, as well as the seasonal variation of the influent concentration. Among the monitored pollutants, some illicit drugs (i.e. Benzoylecgonine, 11 -nor-carboxy-Delta 9-tetrahydrocannabinol) and Ketoprofen showed the highest concentrations in the influent and were also the most frequently detected in the wastewater; nonetheless, the plants were capable of removing these pollutants at high extent (median removal value of 70 %, 65 % and 74 %, respectively). On the other side, steroid concentrations were in most cases under the detection limits. About the type of lay-out, the comparison of the efficiency obtained by the different plants showed that combination of secondary and tertiary treatment provides the best removal for most of the target Organic Micropollutants. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.