Knowledge of thermo-hydro-mechanical (THM) coupling process is important for rock hydrofracturing of enhanced geothermal systems (EGS). The THM coupling parameters (e.g. thermal conductivity, water permeability and Biot's coefficient, etc) of granite undergoing treatment with heating and water cooling (HWC) were measured using laboratory tests. A large number of cracks inside the granite are caused by the uncoordinated deformation of minerals and the tensile stress induced by the treatment of HWC were clearly observed by scanning electron microscope (SEM), resulting in degradations of physicomechanical behavior and capacity of heat transmission, and increases of effective stress and connectivity of transport path. Compared with the treatments of heating and natural cooling or heating in realtime in previous studies, the temperature threshold of THM coupling parameters are advanced for HWC treated granite, especially for thermal conductivity, water permeability, Biot's coefficient and brittle-plastic transition. Prediction models for THM coupling parameters are established based on the correlation analysis. The predictions are in good agreement with the experimental observations. The results are likely to provide an outlet for understanding the characteristics of dry hot rock undergoing hydraulic fracturing or thermal stimulation, especially for the variations and predictions in THM coupling parameters. (c) 2020 Elsevier Ltd. All rights reserved.