Photodynamic Graphene Oxide Combined Alginate Hydrogel for Controlled Drug Release

Jun-Sung Oh; Eun-Jung Lee

Macromolecular Research, Vol.29, No.5, 383-390, May, 2021

DOI10.1007/s13233-021-9048-x Export Citation

Photodynamic Graphene Oxide Combined Alginate Hydrogel for Controlled Drug Release

Jun-Sung Oh, and Eun-Jung Lee^†

Department of Nano-biomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Chungnam 31116, Korea

E-mail:

Graphene is a widely used material as a therapeutic agent (drug) carrier due to its low toxicity, high surface area, specific flake-shape, 2-dimensional structure and geometry. In order to evaluate the efficiency of drug delivery improved by using graphene oxide as a drug carrier, drug release experiment using Cytochrome-C (Cyto-C), a model drug, was carried out. First of all, different ratios of Cyto-C were combined with 100 mg GO to investigate the best drug-loading efficiency so that the best loading ratio was confirmed with Cyto-C:GO of 1:2. Alginate hydrogel (Alg hydrogel) and Alginate-Graphene oxide hydrogel (Alg-GO hydrogel) were fabricated by cross-linking in 0.1 M CaCl2 solution. Characterization of the hydrogels was confirmed by Fourier transform infrared (FT-IR) and scanning electron microscope (SEM) analysis. The drug efficiency by the ratio of graphene oxide to Cyto-C was compared by ultraviolet visible spectrophotometer (UV-VIS). The difference in drug release behavior in hydrogels was confrimed by drug release test. The Alg-GO hydrogel exhibited slow and steady release compared to that of alginate hydrogel as control. In this study, we demonstrated that applying graphene oxide as a drug carrier affects in control of drug release behavior.

Keywords:graphene oxide;controlled drug delivery;photothermal;burst release

[References]

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[2] Youn HW, Kang KW, Chung JK, Lee DS, Nucl. Med. Mol. Imaging, 42, 337 (2008)

[3] Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KS, Pharm. Innov. J., 1 (2012)

[4] Langer R, Nature, 392(6679), 5 (1998)

[5] Ciofani G, Raffa V, Menciassi A, Dario P, Biomed. Microdevices, 10, 131 (2008)

[6] Langer R, Science, 249, 1527 (1990)

[7] Pardakhty A, Varshosaz J, Rouholamini A, Int. J. Pharm., 328, 130 (2007)

[8] Allen TM, Drugs, 56, 747 (1998)

[9] Zhao C, Pandit S, Fu Y, Mijakovic I, Jesorka A, Liu J, RSC Adv., 6, 38124 (2016)

[10] Jeong JT, Choi MK, Sim Y, Lim JT, Kim GS, Seong MJ, Hyung JH, Kim KS, Umar A, Lee SK, Sci. Rep., 6, 33835 (2016)

[11] Jokar S, Pourjavadi A, Adeli M, RSC Adv., 4, 33001 (2014)

[12] Yang X, Wang Y, Huang X, Ma Y, Huang Y, Yang R, Duan H, Chen Y, J. Mater. Chem., 21, 3448 (2011)

[13] Weng F, Yin J, Bao F, Gao J, Ma R, Yan S, Liu Y, Ding H, Int. J. Polym. Mater., 67, 307 (2018)

[14] Shen H, Zhang L, Liu M, Zhang Z, Theranostics, 2, 283 (2012)

[15] Wang K, Ruan J, Song H, Zhang J, Wo Y, Guo S, Cui D, Nanoscale Res. Lett., 6, 8 (2010)

[16] Zhu Y, Li W, Sci. China, Ser. B: Chem., 51, 1021 (2008)

[17] Mazaheri M, Akhavan O, Simchi A, Appl. Surf. Sci., 301, 456 (2014)

[18] Nayak TR, Andersen H, Makam VS, Khaw C, Bae S, Xu X, Ee PLR, Ahn JH, Hong BH, Pastorin G, Ozyilmaz B, ACS Nano, 5, 4670 (2011)

[19] Augst AD, Kong HJ, Mooney DJ, Macromol. Biosci., 6, 623 (2006)

[20] Sennerby L, Rostiund T, Albrektsson B, Albrektsson T, Biomaterials, 8, 49 (1987)

[21] Li Z, Ramay HR, Hauch KD, Xiao D, Zhang M, Biomaterials, 26, 3919 (2005)

[22] Koch AL, Anal. Biochem., 38, 252 (1970)

[23] Heatley NG, Biochem. J., 38, 61 (1944)

[24] Reddy SV, Srinivas PV, Praveen V, Kishore KH, Raju BC, Murthy S, Rao JM, Phytomedicine, 11, 697 (2004)

[25] Volz MG, Soil Sci. Soc. Am. J., 41, 549 (1977)

[26] Sartori C, Finch DS, Ralph B, Gilding K, Polymer, 38(1), 43 (1997)

[27] Li P, Dai YN, Zhang JP, Wang AQ, Wei Q, Int. J. Biomed. Sci., 4, 221 (2008)

[28] Acik M, Lee G, Mattevi C, Pirkle A, Wallace RM, Chhowalla M, Cho K, Chabal Y, J. Phys. Chem. C, 115, 19761 (2011)

[29] Das AK, Srivastav M, Layek RK, Uddin ME, Jung D, Kim NH, Lee JH, J. Mater. Chem. A, 2, 1332 (2014)

[30] Page AJ, Chou CP, Pham BQ, Witek HA, Irle S, Morokuma K, Phys. Chem. Chem. Phys., 15, 3725 (2013)

[31] Yu M, Zhou K, Zhang F, Zhang D, Ceram. Int., 40, 12617 (2014)

[32] Netz DJA, Sepulveda P, Pandolfelli VC, Spadaro ACC, Alencastre JB, Bentley MVLE, Marchetti JM, Int. J. Pharm., 213, 117 (2001)

[33] Oner M, YetizE, Ay E, Uysal U, Ceram. Int., 37, 2117 (2011)

[34] Magrez A, Kasas S, Salicio V, Pasquier N, Seo JW, Celio M, Catsicas S, Schwaller B, Forro L, Nano Lett., 6, 1121 (2006)

[35] Ma X, Tao H, Yang K, Feng L, Cheng L, Shi X, Li Y, Guo L, Liu Z, Nano Res., 5, 199 (2012)

[36] Shi J, Wang L, Zhang J, Ma R, Gao J, Liu Y, Zhang C, Zhang Z, Biomaterials, 35, 5847 (2014)

[37] Zhang B, He J, Shi M, Liang Y, Guo B, Chem. Eng. J., 400, 125994 (2020)

[38] Li M, Liu X, Tan L, Cui Z, Yang X, Li Z, Zhang Y, Yeung KWK, Chu PK, Wu S, Biomater. Sci., 6, 2110 (2018)

[39] Phan TTV, Huynh TC, Oh J, Polymers, 11, 1679 (2019)

[40] Akinkunmi EO, Adesunkanmi AR, Lamikanra A, Afr. Health. Sci., 14, 802 (2014)

[41] Yan T, Kong S, Quyang Q, Li C, Hou T, Chen Y, Li S, Mar. Drugs, 18, 233 (2020)

[42] Liu S, Zeng TH, Hofmann M, Burcombe E, Wei J, Jiang R, Kong J, Chen Y, ACS Nano, 5, 6971 (2011)

[43] Khan MS, Abdelhamid HN, Wu HF, Colloids Surf. B: Biointerfaces, 127, 281 (2015)