Enhanced bone regeneration using poly(trimethylene carbonate)/ vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling agent modified hydroxyapatite nanoparticles

Jian He; Xulin Hu; Luyao Xing; Dongliang Chen; Lijun Peng; Gaofeng Liang; Chengdong Xiong; Xiangchun Zhang; Lifang Zhang

Journal of Industrial and Engineering Chemistry, Vol.99, 134-144, July, 2021

DOI10.1016/j.jiec.2021.04.021 Export Citation

Enhanced bone regeneration using poly(trimethylene carbonate)/ vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling agent modified hydroxyapatite nanoparticles

Jian He, Xulin Hu¹, Luyao Xing¹, Dongliang Chen¹, Lijun Peng², Gaofeng Liang, Chengdong Xiong^{1, †}, Xiangchun Zhang^{3, †}, and Lifang Zhang^{1, †}

College of Medical, Henan University of Science and Technology, Luoyang 471023, China
¹Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China
²Changzhou Institute of Chemistry, Changzhou, Jiangsu 213000, China
³Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China

E-mail:, ,

Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cell attachment, migration, proliferation, and differentiation. To enhance the drug loading, degradation control, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications, we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs, modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. The fabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties, and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity,100 mm pore size, and 208.2 MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12 weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreased inflammation response and promoted bone regeneration, suggesting its use as a bioactive structure in bone tissue engineering.

Keywords:Porous microspheres;Modified hydroxyapatite nanoparticles;(KHA NPs);Vancomycin hydrochloride;Inflammation response

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[Referenced By]

[1] Robbins S, Lauryssen C, Songer MN, Clin. Spine Surg., 30, E192 (2017)

[2] Karp JM, Langer R, Curr. Opin. Biotechnol., 18, 454 (2007)

[3] Zhang YB, Liu XC, Zeng L, Zhang J, Zuo JL, Zou J, Ding JX, Chen XS, Adv. Funct. Mater., 29, 190327 (2019)

[4] Wan QQ, Qin WP, Shen MJ, Ma YX, Li B, Liu SY, Tay FR, Jiao K, Niu LN, Adv. Funct. Mater., 30 (2020)

[5] Gupta V, Khan Y, Berkland CJ, Laurencin CT, Detamore MS, Annu. Rev. Biomed. Eng., 19, 135 (2017)

[6] Qutachi O, Vetsch JR, Gill D, Cox H, Scurr DJ, Hofmann S, Muller R, Quirk RA, Shakesheff KM, Rahman CV, Acta Biomater., 10, 5090 (2014)

[7] Minardi S, Pandolfi L, Taraballi F, Rosa ED, Yazd IK, Liu XW, Ferrari M, Tasciotti E, ACS Appl. Mater. Interfaces, 7, 16364 (2015)

[8] Mohammadi M, Shaegh SAM, J. Control. Release, 274, 35 (2018)

[9] Fan DM, De Rosa E, Murphy MB, Peng Y, Smid CA, Chiappini C, Liu XW, Simmons P, Weiner BK, Ferrari M, Tasciotti E, Adv. Funct. Mater., 22(2), 282 (2012)

[10] Heo DN, Castro NJ, Lee SJ, Noh H, Zhu W, Zhang LJG, Nanoscale, 9, 5055 (2017)

[11] Wang XC, Xue JM, Ma B, Wu JF, Chang J, Gelinsky M, Wu C, Adv. Mater., 32 (2020)

[12] Green JJ, Elisseeff JH, Nature, 540(7633), 386 (2016)

[13] Amiryaghoubi N, Fathi M, Pesyan NN, Samiei M, Barar J, Omidi Y, Med. Res. Rev., 40, 1833 (2020)

[14] Dinarvand R, Alimorad MM, Amanlou M, Akbari H, Biomed. Mater. Res., 75A(1), 185 (2005)

[15] Zhang Z, Kuijer R, Bulstra SK, Grijpma DW, Feijen J, Biomaterials, 27, 1741 (2006)

[16] Fukushima K, Biomater. Sci., 4, 9 (2015)

[17] Song JS, Kim SG, Oh JS, Appleford M, Oh S, Ong JL, J. Biomed. Mater. Res. A, 99(A), 638 (2011)

[18] Wu H, Lei P, Liu G, Shrike ZY, Yang J, Zhang L, Sci. Rep. U. K., 7, 359 (2017)

[19] Yang T, Cui X, Kao Y, Wang H, Wen J, Colloids Surf. A: Physicochem. Eng. Asp., 499, 123 (2016)

[20] Kanhed S, Awasthi S, Midha S, Nair J, Nisar A, Patel AK, Pandey A, Sharma R, Goel S, Padhyaya AU, Ghosh S, Balani K, Adv. Eng. Mater., 20, 7 (2018)

[21] Stoppel WL, Kaplan DL, Black LD, Adv. Drug Deliv. Rev., 96, 135 (2016)

[22] Morra M, Giavaresi G, Sartori M, Ferrari A, Parrilli A, Bollati D, Baena RRY, Cassinelli C, Fini M, J. Mater. Sci. Mater. Med., 26, 1 (2015)

[23] Sarkar N, Bose S, ACS Appl. Mater. Interfaces, 11, 17184 (2019)

[24] Wang X, Lin MH, Kang YQ, ACS Appl. Mater. Interfaces, 11, 9223 (2019)

[25] Yang L, Yan CZ, Cao WC, Liu ZF, Song B, Wen SF, Zhang C, Shi YS, Yanf SF, Acta Mater., 181, 49 (2019)

[26] Patel R, Lu MY, Diermann SH, Wu A, Pettit A, Huang H, J. Mech. Behav. Biomed., 96, 1 (2019)

[27] He J, Hu XL, Cao JF, Zhang Y , Xiao JP, Peng LJ, Chen DL, Xiong CD, Zhang LF, Carbohydr. Polym., 253, 117198 (2021)

[28] Shefelbine SJ, Simon U, Claes L, Gold A, Gabet Y, Bab I, Augat P, Bone, 36, 480 (2005)

[29] Lai GJ, Shalumon KT, Chen JP, Int. J. Nanomed., 10, 567 (2015)

[30] Shalumon KT, Binulal NS, Deepthy M, Jayakumar R, Manzoor K, Nair SV, J. Macromol. Sci. A, 48, 21 (2010)

[31] Tahriri M, Moztarzadeh F, Appl. Biochem. Biotechnol., 172(5), 2465 (2014)

[32] Chernozem RV, Surmeneva M, Shkarina S, Loza K, Epple M, Ulbricht M, et al., ACS Appl. Mater. Interfaces, 11, 19522 (2019)

[33] Sarker A, Amirian J, Min YK, Lee BT, Int. J. Biol. Macromol., 81, 898 (2015)

[34] Shin JY, Jeong SJ, Lee WK, J. Ind. Eng. Chem., 80, 862 (2019)

[35] Kuang TR, Chen F, Chang LQ, Zhao YN, Fu DJ, Gong X, Peng XF, Chem. Eng. J., 307, 1017 (2017)

[36] Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR, Biomaterials, 27(18), 3413 (2006)

[37] Zhou J, Xu C, Wu G, Cao X, Zhang L, Zhai Z, Zheng Z, Chen X, Wang Y, Acta Biomater., 7, 3999 (2011)

[38] Hu X, He J, Yong X, Lu J, Xiao J, Liao Y, Li Q, Xiong C, Colloids Surf. B: Biointerfaces, 195, 111218 (2020)

[39] Jose G, Shalumon KT, Liao HT, Kuo CY, Chen JP, Int. J. Biol. Macromol., 21(2), 528 (2020)

[40] Recouvreux DOS, Rambo CR, Berti FV, Carminatti CA, Antonio RV, Porto LM, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 31, 151 (2011)

[41] Fischer D, Li YX, Ahlemeyer B, Krieglstein J, Kissel T, Biomaterials, 24(7), 1121 (2003)

[42] Ho ML, Fu YC, Wang GJ, Chen HT, Chang JK, Tsai TH, Wang CK, J. Control. Release, 128(2), 142 (2008)

[43] Fang B, Wan YZ, Tang TT, Gao C, Dai KR, Tissue Eng. A, 15(5), 1091 (2009)

[44] Chen C, Chen J, Wu W, Shi Y, Jin L, Petrini L, Migliavacca F, Biomaterials, 221, 119414 (2019)

[45] Weng L, Rostamzadeh P, Nooryshokry N, Le HC, Golzarian J, Acta Biomater., 9(6), 6823 (2013)

[46] Szlazak K, Vass V, Hasslinger P, Jaroszewicz J, Dejaco A, Idaszek J, Scheiner S, Hellmich C, Swieszkowski W, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 95, 389 (2017)

[47] Kim SS, Min SP, Jeon O, Cha YC, Kim BS, Biomaterials, 27(8), 1399 (2006)