Preparation of hydroxypropyl-β-cyclodextrin-incorporated liposomes and evaluation of their rapid release property

Hana Lim; Soyeong Jin; Youngdo Jeong; Seong-Bo Kim; Dong-Jin Jang; Sung Tae Kim

Journal of Industrial and Engineering Chemistry, Vol.100, 59-62, August, 2021

DOI10.1016/j.jiec.2021.05.002 Export Citation

Preparation of hydroxypropyl-β-cyclodextrin-incorporated liposomes and evaluation of their rapid release property

Hana Lim¹, Soyeong Jin^{2, 3}, Youngdo Jeong^{2, 4}, Seong-Bo Kim^{5, †}, Dong-Jin Jang^{6, †}, and Sung Tae Kim^{7, 8, †}

¹Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Republic of Korea
²Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
³Department of Chemistry, School of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea
⁴Department of HY-KIST Bio-Convergence, Hanyang University, Seoul 04763, Republic of Korea
⁵Bio-Living Engineering Major, Global Leaders College, Yonsei University, Seoul 03722, Republic of Korea
⁶Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chunchoen 24341, Republic of Korea
⁷Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Republic of Korea
⁸Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea

E-mail:, ,

The aim of this study was to investigate the effect of hydroxypropyl-β-cyclodextrin (HPβCD), widely used as a solubility enhancer, on liposomal formulations. To this end, HPβCD was added to fabricate liposomes during the hydration process, and their physicochemical properties were evaluated. The Fourier transform infrared and nuclear magnetic resonance spectra revealed that HPβCD could interact with the model drug, ceftazidime (CAZ), and with phosphatidylcholine, a main component of liposomes. This leads to a rapid release of CAZ depending on the concentration of HPβCD. Nanosized HPβCD-incorporated liposomes complied with Korsmeyer.Peppas kinetics, and the release of drug increased without significant changes in the release pattern. Our approach, which relied on supramolecule-related interactions, could provide new insights into other lipid-based formulations for accelerating drug-release properties.

Keywords:Hydroxypropyl-β-cyclodextrin;Liposome;Rapid release;Ceftazidime

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[2] Loh GOK, Tan YTF, Peh KK, Asian J. Pharm. Sci., 11, 536 (2016)

[3] Tang P, Li S, Wang L, Yang H, Yan J, Li H, Carbohydr. Polym., 131, 297 (2015)

[4] Loftsson T, Brewster ME, Masson M, Am. J. Drug Deliv., 2, 261 (2004)

[5] Leonardi D, Bombardiere ME, Salomon CJ, Int. J. Biol. Macronol., 62, 543 (2013)

[6] Swaminathan S, Pastero L, Serpe L, Trotta F, Vavia P, Aquilano D, Trotta M, Zara G, Cavalli R, Eur. J. Pharm. Biopharm., 74, 193 (2010)

[7] Castronuovo G, Niccoli M, Bioorg. Med. Chem., 14, 3883 (2006)

[8] Gidwani B, Vyas A, Biomed. Res. Int., 2015 (2015)

[9] Son GH, Lee BJ, Cho CW, J. Pharm. Invest., 47, 287 (2017)

[10] Charrois GJ, Allen TM, Biochim. Biophys. Acta Biomembr., 1663, 167 (2004)

[11] Fonseca C, Simoes S, Gaspar R, J. Control. Release, 83, 273 (2002)

[12] Ribeiro LN, Alcantara A, Rodrigues da Silva GH, Franz-Montan M, Nista SV, Castro SR, Couto VM, Guilherme VA, de Paula E, Int. J. Polym. Sci., 2017 (2017)

[13] Huang Z, London E, Langmuir, 29(47), 14631 (2013)

[14] Zhang H, Springer, pp.17 (2017).

[15] Misiuk W, J. Mol. Liq., 224, 387 (2016)

[16] Yuan C, Jin Z, Xu X, Carbohydr. Polym., 89, 492 (2012)

[17] Rajendiran N, Siva S, Carbohydr. Polym., 101, 828 (2014)

[18] Hatzi P, Mourtas S, Klepetsanis PG, Antimisiaris SG, Int. J. Pharm., 333, 167 (2007)

[19] Tan D, Yuan P, Annabi-Bergaya F, Liu D, Wang L, Liu H, He H, Appl. Clay Sci., 96, 50 (2014)

[20] Gouda R, Baishya H, Qing Z, J. Dev. Drugs, 6, 1 (2017)