화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.101, 307-323, September, 2021
DOI10.1016/j.jiec.2021.05.051  Export Citation
Synthesis, physical and mechanical properties of amphiphilic hydrogels based on polycaprolactone and polyethylene glycol for bioapplications: A review
Alaleh Dabbaghi1, Ali Ramazani1, 2, †, Negin Farshchi3, Aram Rezaei4, Ali Bodaghi5, and Sobhan Rezayati1
  • 1Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan 45371-38791, Iran
  • 2Department of Biotechnology, Research Institute of Modern Biological Techniques (RIMBT), University of Zanjan, Zanjan 45371-38791, Iran
  • 3Leibniz Institute of Polymer Research Dresden, Hohe Str. 6, 01069 Dresden, Germany
  • 4Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 5Department of Chemistry, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran
E-mail:
During the past decades, amphiphilic hydrogels found versatile applications in biomaterial field due to their suitable mechanical properties and control on releasement of hydrophobic substrates. Polyethylene glycol (PEG) and polycaprolactone (PCL) are FDA approved polymers that were used together in lots of research articles due to their complementary properties. This review focused on synthetic methods, physical, and mechanical properties as well as sol.gel-sol phase transition behavior of amphiphilic hydrogels based on polyethylene glycol (PEG) and polycaprolactone (PCL). Physical hydrogels were formed base on the hydrophobic interaction between copolymers of PCL and PEG or based on supramolecular chemistry. Also, chemical hydrogels synthesized via free radical crosslinking and chemical coupling reaction between functionalized prepolymers. Both types of physical and chemical hydrogels are biocompatible and biodegradable. Physical hydrogels are thermo-sensitive and were used as injectable hydrogels that can be sensitive to pH or other triggers. In addition, chemical hydrogels could be used as tissue scaffolds according to their mechanical properties.
Keywords:Amphiphilic hydrogels;PCL;PEG;Biomaterial;Biodegradable polymers
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