화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.102, 135-145, October, 2021
DOI10.1016/j.jiec.2021.07.002  Export Citation
Immobilization of antibacterial copper metal-organic framework containing glutarate and 1,2-bis(4-pyridyl)ethylene ligands on polydimethylsiloxane and its low cytotoxicity
Do Nam Lee†, Kihak Gwon, Youngmee Kim1, Hyunjun Cho2, and Seonhwa Lee
  • Ingenium College of Liberal Arts (Chemistry), Kwangwoon University, Seoul 01897, Republic of Korea
  • 1NanoBio-Energy Materials Center and Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea
  • 2Department of Chemistry, Dongguk University, Seoul 04620, Republic of Korea
E-mail:
Metal-organic frameworks (MOFs) that include bioactive metals may exhibit activity against various microbes through metal-ligand bond cleavage to release metal ions or ligands into the media. However, controlled release over an extended time is required to avoid toxicity due to excess metal ions for successful clinical applications. Recently, copper-based MOFs (Cu-MOFs), which showed sustained release capability, porosity, and structural flexibility, exhibited antibacterial properties. Herein, toward the development of regenerative biomedical applications, we immobilized a robust Cu-MOF containing glutarate and 1,2-bis(4-pyridyl)ethylene ligands within biocompatible polydimethylsiloxane (PDMS) via simple hydrosilylation at 25 °C. The PDMS-immobilized Cu-MOF (PDMS@Cu-MOF) exhibited concentration-dependent antibacterial activities against five bacterial strains: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus. Furthermore, PDMS@Cu-MOF maintained the physical and thermal properties of PDMS and showed low cytotoxicity toward mouse embryonic fibroblasts. Owing to its antibacterial properties and low cytotoxicity, PDMS@Cu-MOF exhibited potential for medicinal applications, such as implants, skin disease treatment, wound healing, and drug delivery.
Keywords:Copper metal-organic framework;Polydimethylsiloxane;Hydrosilylation;Immobilization;Antibacterial activity;Cytotoxicity
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