해조다당류를 이용한 상호침투 고분자 네트워크의 시간과 방법에 따른 콘택트렌즈의 특성변화 연구

고나영; 이필헌; 성아영; 이현미; Na-Young Ko; Pil Heon Lee; A-Young Sung; Hyun Mee Lee

Polymer(Korea), Vol.45, No.5, 775-782, September, 2021

DOI10.7317/pk.2021.45.5.775 Export Citation

해조다당류를 이용한 상호침투 고분자 네트워크의 시간과 방법에 따른 콘택트렌즈의 특성변화 연구

Study on Characteristic Changes of Contact Lenses According to Interpenetrating Polymer Network Time and Method Using Seaweed Polysaccharide

고나영, 이필헌, 성아영^†, 이현미^†

대구가톨릭대학교 안경광학과

Na-Young Ko, Pil Heon Lee, A-Young Sung^†, and Hyun Mee Lee^†

Department of Optometry & Vision Science, College of Bio and Medical Science, Daegu Catholic University, Hayang-Ro 13-13, Gyeongsan, Gyeongbuk 38430, Korea

E-mail:,

초록

본 연구는 하이드로겔 콘택트렌즈에 알지네이트와 카라기난과 같은 해조다당류를 상호침투 고분자 네트워크를 진행하여 interpenetrating polymer network(IPN) 시간에 따른 콘택트렌즈의 특성 변화를 살펴보았다. IPN은 알지네이트와 카라기난을 이용하여 semi-IPN과 full-IPN으로 4주 동안 진행하였다. 콘택트렌즈의 기능은 함수율, 산소 투과율, 접촉각, 단백질 흡착, 그리고 항균성 등을 측정하여 평가하였다. IPN 시간이 증가함에 따라 콘택트렌즈의 모든 물리·화학적 성질이 향상되었다. 산소과율과 습윤성은 카라기난보다 알지네이트를 사용했을 때가 더 높았다. 함수율과 산소투과율은 semi-IPN 방법이 full-IPN 방법보다 좋았으며 습윤성은 full-IPN 방법이 더 많이 향상되었다. 해조다당류는 하이드로겔 콘택트렌즈의 기능 향상에 도움이 되며 IPN 시간이 길수록 성능이 더욱 증가함을 확인하였다.

We investigated the change in the characteristics of contact lenses according to the interpenetrating polymer network (IPN) time and method when a contact lens was dual-networked with alginate and carrageenan. The IPN was formed for four weeks using semi-IPN and full-IPN. The functions of contact lenses were assessed based on the measurement of water content, oxygen permeability, contact angle, protein adsorption, and antimicrobial. With the increase in IPN time, all physical and chemical properties of contact lenses were improved. The oxygen permeability and wettability were better when using alginate than using carrageenan. The water content and oxygen permeability were better when using the semi-IPN method than using the full-IPN method, whereas wettability was further improved when using the full-IPN method. The result of this study verified that seaweed polysaccharides were helpful in the functional improvement of hydrogel contact lenses, and performance was better in a longer IPN time.

Keywords:contact lens;alginate;carrageenan;interpenetrating polymer network;polysaccharide

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[2] Sirkecioglu A, Mutlu HB, Citak C, Koc A, Guner FS, Polym. Eng. Sci., 54(5), 1182 (2014)

[3] Garrett Q, Laycock B, Garrett RW, Invest. Ophthalmol. Vis. Sci., 41, 1687 (2000)

[4] Refojo MF, Contact Lenses, The CLAO Guide to Basic Science and Clinical Practice, New York, pp.1 1991.

[5] Nichols JJ, Ziegler C, Mitchell GL, Nichols KK, Invest. Ophthalmol. Vis. Sci., 46, 1911 (2005)

[6] Carney FP, Nash WL, Sentell KB, Invest. Ophthalmol. Vis. Sci., 49, 120 (2008)

[7] Maldonado-Codina C, Efron N, Optom. Vis. Sci., 81, 442 (2004)

[8] Han YA, Lee EM, Ji BC, Fibers Polym., 9, 393 (2008)

[9] Sperling LH, Hu R, Polymer Blends Handbook, pp417 2003.

[10] Matricardi P, Di Meo C, Coviello T, Hennink WE, Alhaique F, Adv. Drug Deliv. Rev., 65, 1172 (2013)

[11] Sperling LH, Mishra V, Polym. Advan. Techol., 7, 197 (1996)

[12] Thambi T, Phan VHG, Lee DS, Macromol. Rapid Commun., 37(23), 1881 (2016)

[13] Silva SS, Gomes JM, Rodringues LC, Reis RL, Mar. Drugs, 18, 346 (2020)

[14] Molinski TF, Dalisay DS, Lievens SL, Saludes JP, Nat. Rev. Drug. Discov., 8, 69 (2009)

[15] Sahoo DR, Biswal T, SN Appl. Sci., 3, 1 (2021)

[16] Puscaselu RG, Lobiue A, Dimian M, Covasa M, Polymers, 12, 2417 (2020)

[17] Khotimchenko, Tiasto M, Kalitnik VA, Begun M, Khotimchenko R, et al., Carbohydr. Polym., 246, 116568 (2020)

[18] Shchipunov YA, Polym. Sci. Ser. A, 62, 54 (2020)

[19] Kim SJ, Park SJ, Kim SI, React. Funct. Polym., 55(1), 53 (2003)

[20] Seredych M, Mikhalovska L, Mikalovsky S, Gogotsi Y, C-J Carbon Res., 4, 3 (2018)

[21] Efron N, Morgan P, Camerron, Lan D, Optom. Vis. Sci., 84, 328 (2007)

[22] Tran NPD, Ting CC, Lin CH, Yang MC, Polymers, 12, 2087 (2020)

[23] Lee SB, Park EK, Lim YM, Cho SK, Kim SY, Lee YM, Nho YC, J. Appl. Polym. Sci., 100(6), 4439 (2006)

[24] Hu X, Lu L, Xu C, Li X, Int. J. Biol. Macromol., 72, 403 (2015)

[25] Hoffman AS, Adv. Drug Deliv. Rev., 54, 3 (2002)

[26] Fonn D, Bruce AS, Eye Contact Lens, 31, 247 (2005)

[27] Tran NPD, Ting CC, Lin CH, Yang MC, Polymers, 12, 2087 (2020)

[28] Tranoudis I, Efron N, Cont. Lens Anterior Eye, 27, 115 (2004)

[29] Luensmann D, Jones L, Cont. Lens Anterior Eye, 31, 179 (2008)

[30] Nicolson PC, Vogt J, Biomaterials, 22, 3273 (2001)

[31] Allansmith MR, Korb DR, Greiner JV, Henriquez AS, Simon MA, Finnemore VM, Am. J. Ophthalmol., 83, 697 (1997)

[32] Noh H, Vogler EA, Biomaterials, 28, 405 (2007)

[33] Prime KL, Whitesides GM, Science, 252, 1164 (1991)

[34] Hohn S, Virtanen S, Boccaccini AR, Appl. Surf. Sci., 464, 212 (2019)

[35] Laurienzo P, Mar. Drugs, 8, 2435 (2010)