화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.104, 468-477, December, 2021
DOI10.1016/j.jiec.2021.08.042  Export Citation
Shape-dependent intracellular uptake of metal.organic framework nanoparticles
Se-Na Kim1, Chun Gwon Park2, 3, Chang Hee Min4, Seung Ho Lee1, Yun Young Lee2, 5, Na Kyeong Lee3, and Young Bin Choy1, 4, †
  • 1Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea
  • 2Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
  • 3Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea
  • 4Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea
  • 5Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
E-mail:
Metal.organic framework (MOF) nanoparticles are promising carriers for the internal delivery of therapeutics to the cells; however, the effects of their shape on cellular uptake have not yet been clearly evaluated. Therefore, we synthesized biocompatible Fe-based MOF nanoparticles of two distinct shapes.rods and octahedrons (NH2-MIL-88B(Fe)-ROD and NH2-MIL-88B(Fe)-OCTA, respectively).and evaluated their cellular uptake kinetics and mechanisms using three different cell lines (HeLa, MDA-MB-231, and L929). Although both nanoparticles possessed the same constituent metal, organic linkers, and thus, crystalline structures, a more rapid uptake was observed with NH2-MIL-88B(Fe)-OCTA, whereas NH2-MIL-88B(Fe)- ROD were endocytosed in a more sustained manner. This could be ascribed to the large number of sharp edges available in NH2-MIL-88B(Fe)-OCTA particles; hence, there were more points of expedited entry into the cells via a clathrin-mediated pathway. The findings herein provide important information for the application of the MOF nanoparticles as intracellular drug delivery carriers, especially when they can be prepared in different shapes with the same composition.
Keywords:Metal-organic framework;Nanoparticles;Shape;Intracellular delivery;Endocytosis
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