The health awareness that has arisen from the COVID pandemic has been translated into inter-est in studying the contagion methods of airborne viruses. The cough mechanism is one cause of virion spread. To analyze this phenomenon, computational fluid dynamics (CFD) simulations of the human cough have been set up in closed room conditions. Fundamental droplet, air, and thermody-namic conditions for the problem have been extracted from the literature and applied to the simu-lations performed. Three typologies of cough have been computed corresponding to the maximum, minimum, and mean peak cough velocities of the human being, and their corresponding injection profiles. Coughs were simulated in transient conditions and the droplets were tracked following an Eulerian-Lagrangian approach and large eddy simulation (LES) formulation for the turbulence phe-nomenon. Results revealed droplet travel distances of almost 2 m for the strongest cough case. Also, the presence of droplets smaller than 5 mu m of diameter, the main virus spreader, was considerably larger than particles of bigger size. Additionally, most of the droplets evaporate or fall to the ground within 2 s after their injection. The remaining ones that stayed above the waistline or remained suspended in the air followed trajectories coming from buoyancy effects rather than being driven by the initial velocity profile. Moreover, it was found how almost the totality of the droplets expelled followed a trajectory towards the floor. Droplets that did not evaporate during the fluid injection became airborne for at least 5 seconds after the coughing.