화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Chemical Engineering Research, Vol.59, No.4, 493-502, November, 2021
DOI10.9713/kcer.2021.59.4.493  Export Citation
Kinetics, Isotherm and Adsorption Mechanism Studies of Letrozole Loaded Modified and Biosynthesized Silver Nanoparticles as a Drug Delivery System:Comparison of Nonlinear and Linear Analysis
Mahsa PourShaban, Elham Moniri1, Raheleh Safaeijavan2, †, and Homayon Ahmad Panahi3
  • Department of Biotechnology, Science and research Branch, Islamic Azad University, Tehran, Iran
  • 1Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
  • 2Department of Biochemistry and Biophysics, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
  • 3Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran
E-mail:
We prepared and investigated a biosynthesized nanoparticulate system with high adsorption and release capacity of letrozole. Silver nanoparticles (AgNPs) were biosynthesized using olive leaf extract. Cysteine was capped AgNPs to increase the adsorption capacity and suitable interaction between nanoparticles and drug. Morphology and size of nanoparticles were confirmed using transmission electron microscopy (TEM). Nanoparticles were spherical with an average diameter of less than 100 nm. Cysteine capping was successfully confirmed by Fourier transform infrared resonance (FTIR) spectroscopy and elemental analysis (CHN). Also, the factors of letrozole adsorption were optimized and the linear and non-linear forms of isotherms and kinetics were studied. Confirmation of the adsorption data of letrozole by cysteine capped nanoparticles in the Langmuir isotherm model indicated the homogeneous binding site of modified nanoparticles surface. Furthermore, the adsorption rate was kinetically adjusted to the pseudo-second-order model, and a high adsorption rate was observed, indicating that cysteine coated nanoparticles are a promising adsorbent for letrozole delivery. Finally, the kinetic release profile of letrozole loaded modified nanoparticles in simulated gastric and intestinal buffers was studied. Nearly 40% of letrozole was released in simulated gastric fluid with pH 1.2, in 30 min and the rest of it (60%) was released in simulated intestinal fluid with pH 7.4 in 10 h. These results indicate the efficiency of the cysteine capped AgNPs for adsorption and release of drug letrozole for breast cancer therapy.
Keywords:Silver nanoparticles;Cysteine;Drug delivery;Letrozole;Non-linear and linear
  1. Sriharitha PJ, Swaroop H, J. Mater. Sci., 4, 1 (2006)
  2. Yang HW, Hua MY, Liu HL, Huang CY, Wei KC, Nanotechnology, Science and Applications, 5, 73(2012).
  3. Jayapriya E, Lalitha P, International Journal of ChemTech Research, 5, 2985 (2013).
  4. Thakare SR, Ramteke SM, Catal. Commun., 102, 21 (2017)
  5. Prusty K, Swain SK, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 85, 130 (2017)
  6. Li L, et al., Food Chem., 215, 477 (2017)
  7. Juling S, et al., Food Chem Toxicol., 97, 327 (2016)
  8. Wilding LA, et al., Nanotoxicology, 10, 513 (2016)
  9. Bergin IL, et al., Nanotoxicology, 10, 352 (2016)
  10. Shahare B, Yashpal M, Toxicol Mech Methods, 23, 161 (2013)
  11. Prabhu S, Poulose EK, International Nano Letters, 2, 32(2012).
  12. Shanmugavadivu M, Kuppusamy S, Ranjithkumar R, Am. J. Adv. Drug. Deliv, 2, 174 (2014)
  13. Khalil MM, Ismail EH, El-Baghdady KZ, Mohamed D, Arabian Journal of Chemistry, 7, 1131 (2014).
  14. Cho K, Wang X, Nie S, Shin DM, Clinical Cancer Research, 14, 1310 (2008)
  15. Gong R, Chen G, Saudi Pharmaceutical Journal, 24, 254 (2016)
  16. Sperling RA, Parak WJ, Physical and Engineering Sciences, 368, 1333 (2010).
  17. Barzegar-Jalali M, et al., Journal of Pharmacy and Pharmaceutical Sciences, 11, 167 (2008).
  18. Panahi HA, Nezhati MN, Kashkoieh RA, Moniri E, Galaev IY, Korean J. Chem. Eng., 30(9), 1722 (2013)
  19. Geisler J, Helle H, Ekse D, Duong NK, Evans DB, Nordbø Y, Aas T, Lønning PE, Clinical Cancer Research, 14, 6330 (2008)
  20. Bhatnagar AS, Breast Cancer Research and Treatment, 105, 7 (2007).
  21. Kalaki ZA, Safaeijavan R, Ortakand MM, Archives of Advances in Biosciences, 8, 24 (2007).
  22. Freitas AF, Mendes MF, Coelho GLV, J. Chem. Thermodyn., 39(7), 1027 (2007)
  23. Langmuir I, Journal of the American Chemical Society, 40, 1361 (1918).
  24. Hall KR, Eagleton LC, Acrivos A, Vermeulen T, Ind. Eng. Chem. Fundam., 5, 212 (1966)
  25. Hashemian S, Ardakani MK, Salehifar H, CuFe2O4 Composite(2013).
  26. Thabet MS, Ismaiel AM, Journal of Encapsulation and Adsorption Sciences, 6, 70(2016).
  27. Ayawei N, Ekubo A, Wankasi D, Dikio E, Oriental Journal of Chemistry, 31, 1307 (2015).
  28. Sahoo RT, Prelot B, Nanomaterials for the Detection and Removal of Wastewater Pollutants, 161 (2020).
  29. Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M, Biotechnol. Prog., 22(2), 577 (2006)
  30. Ahmad N, Sharma S, Green synthesis of silver nanoparticles using extracts of Ananas comosus(2012).
  31. Templeton AC, Chen SW, Gross SM, Murray RW, Langmuir, 15(1), 66 (1999)
  32. Konicki W, Aleksandrzak M, Moszynski D, Mijowska E, J. Colloid Interface Sci., 496, 188 (2017)
  33. Mondal N, Pal T, Ghosal S, Die Pharmazie-An International Journal of Pharmaceutical Sciences, 63, 361 (2008).
  34. Dey SK, Mandal B, Bhowmik M, Ghosh LK, Brazilian Journal of Pharmaceutical Sciences, 45, 5851(2009).