화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.29, No.11, 785-790, November, 2021
DOI10.1007/s13233-021-9091-7  Export Citation
Fabrication of Nanoparticles based on Hesperidin-Loaded Chitosan-Functionalized Fe3O4: Evaluation of In vitro Antioxidant and Anticancer Properties
Mahboobeh Zare†, Malihe Norouzi Sarkati1, and Somayeh Rahaiee2
  • Faculty of medicinal plants, Amol University of Special Modern Technologies, Amol, Iran
  • 1Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
  • 2Department of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
E-mail:
Hesperidin (HD) as a flavanone glycoside has pharmacological activities such as anti-inflammatory, antioxidant, and anti-cancer properties. However, poor solubility and bioavailability of hesperidin restrict its therapeutic effects. In this work, chitosan-functionalized Fe3O4 magnetic nanoparticles (Cs-f-Fe3O4 MNPs) were prepared to carry hesperidin. Hesperidin was isolated and purified from orange peel and then it was efficiently loaded into the synthesized magnetic nanoparticles (HD-Cs-f-Fe3O4 MNPs). The antioxidant activity of synthesized MNPs was determined by 2,2'-diphenyl-1- picrylhydrazyl (DPPH) free radical method. HD-Cs-f-Fe3O4 MNPs have exhibited high DPPH scavenging activity and their antioxidant effect increased as the concentrations increased. The cytotoxicity of prepared MNPs were studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. HD-Cs-f-Fe3O4 MNPs demonstrated a greater toxicity against MCF-7 cells compared to Cs-f-Fe3O4 MNPs. The toxicity of hesperidin-loaded chitosan-functionalized Fe3O4 MNPs against cancerous cells makes them as promising candidates for further studies in the cancer treatment.
Keywords:Hesperidin;Iron oxide nanoparticle;Antioxidant;MTT assay
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