Two Luminescent Cd(II) Coordination Polymers: Enhancement Activity on Pancreatic Cancer Combined with Biliary Stent Placement and 125I Particles

Jie-Peng Jia; Quan Shao; Ying-Kai Wang; Bo Qian; Wen Zhang; Tao Hu; Ji-Jun Zhang

Macromolecular Research, Vol.29, No.11, 818-824, November, 2021

DOI10.1007/s13233-021-9087-3 Export Citation

Two Luminescent Cd(II) Coordination Polymers: Enhancement Activity on Pancreatic Cancer Combined with Biliary Stent Placement and 125I Particles

Jie-Peng Jia, Quan Shao, Ying-Kai Wang, Bo Qian, Wen Zhang, Tao Hu, and Ji-Jun Zhang^†

Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, P. R. China

E-mail:

With the reaction between bib ligands, 5-substituted isophthalic acid and Cd(II) ions, we produced two coordination polymers in success, that is, [Cd(5-meo-ip) (bib)0.5]n (2) and [Cd(5-me-ip)(bib)(H2O)]n·n(H2O) (1) (bib is 1,4-bis(imidazoly)butane, 5-meo-H2ip is 5-methoxyisophthalic acid, and 5-me-H2ip is 5-methylisophthalic acid). The luminescent performances and thermal stability of the two compounds were also explored. Their anti-pancreatic cancer activity combined with biliary stent placement and 125I particles was evaluated and the specific mechanism was explored as well. Firstly, after the model construction and compound treatment, the weight and volume of the tumor tissue was measured. Next, the apoptosis level of the cancer cells were evaluated with Annexin V-FITC/PI apoptosis assay.

Keywords:5-substituted isophthalic acid;luminescence;coordination polymer;pancreatic cancer

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