This article intends to conduct an analytical simulation for the electroosmosis modulated peristaltic transport of ionic hybrid nano-liquid with Casson model through a symmetric vertical microchannel occupying a homogeneous porous material in the existence of the dominant magnetic field, Hall, and ion-slip currents. The hybrid nano-liquid is acquired by the suspension of silver and silicon dioxide nanoparticles into pure water. The wall slip and convective heating impacts are imposed. The Casson fluid (CF) model is adopted to mimic the rheological behaviour accounting for hybrid nano-liquid. Darcy’s law is applied to evaluate the impact of a porous medium. The Poisson-Boltzmann equation is engaged to accommodate the electric double layer (EDL) in the microchannel. Assumptions of low Reynolds number (LRN), long wavelength (LWL), and Debye-Huckel linearization (DHL) are undertaken to simplify the normalized constitutive equations. Closed-form solutions for the linearized dimensionless resulting equations are achieved by ND-solve code in Mathematica. For a comprehensive physical investigation of the problem under simulation, several graphs are furnished to evaluate the role of emerging thermal and physical parameters in developing the flow patterns and thermal characteristics. Outcomes envisage that Hall, ion-slip, and electro-osmotic parameters have a marked impact on the velocity of the ionic liquid. A decrement in the EDL thickness corresponds to an augmentation in the axial velocity profile in the locality of the channel walls. An increment in radiation parameter results in a demotion in the temperature profile. The pressure gradient is elevated with higher Hall and ion-slip parameters, thermal Grashof number, and electro-osmotic parameter, whereas it is dropped due to higher estimates of Hartmann number. The trapping phenomena under the flow factors are also outlined in brief. The bolus formation is deeply affected by Hall, ion-slip, and electro-osmotic parameters. Outcomes achieved here are expected to shed light on the design and analysis of electroosmotic pumps, microchannel devices, water filtration and purification processes, DNA analyzers, nanoscale electro-fluid thruster designs in-space propulsion, and many more.