One-pot Synthesis of Multifunctional Mn3O4/mesoporous Silica Core/shell Nanoparticles for Biomedical Applications

Dong Jun Lee; Nohyun Lee; Ji Eun Lee

Applied Chemistry for Engineering, Vol.33, No.1, 113-118, February, 2022

DOI10.14478/ace.2021.1108 Export Citation

One-pot Synthesis of Multifunctional Mn3O4/mesoporous Silica Core/shell Nanoparticles for Biomedical Applications

Dong Jun Lee, Nohyun Lee¹, and Ji Eun Lee^{2, †}

School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea
¹School of Advanced Materials Engineering, Kookmin University, Seoul 02707, Republic of Korea
²School of Chemical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea

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Multifunctional nanomaterials based on mesoporous silica nanoparticles (MSN) and metal oxide nanocrystals are among the most promising materials for theragnosis because of their ease of modification and high biocompatibility. However, the preparation of multifunctional nanoparticles requires time-consuming multistep processes. Herein, we report a simple one-pot synthesis of multifunctional Mn3O4/mesoporous silica core/shell nanoparticles (Mn3O4@mSiO2) involving the temporal separation of core formation and shell growth. This simple procedure greatly reduces the time and effort required to prepare multifunctional nanoparticles. Despite the simplicity of the process, the properties of nanoparticles are not markedly different from those of core/shell nanoparticles synthesized by a previously reported multistep process. The Mn3O4@mSiO2 nanoparticles are biocompatible and have potential for use in optical imaging and magnetic resonance imaging.

Keywords:One-pot synthesis;Mesoporous silica;MRI contrast agent

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[1] He IQ, Guo S, Qian Z, Chen X, Chem. Soc. Rev., 44, 6258 (2015)

[2] Cha BG, Kim J, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 11, e1515 (2019).

[3] Yang B, Chen Y, Shi J, Adv. Healthc. Mater., 7, 180026 (2018)

[4] Rastegari E, Hsiao YJ, Lai WY, et al., Pharmaceutics, 13, 1067 (2021)

[5] Kim J, Kim HS, Lee N, Kim T, Kim H, Yu T, Song IC, Moon WK, Hyeon T, Angew. Chem.-Int. Edit., 47, 8438 (2008)

[6] Lee DE, Koo H, Sun IC, Ryu HJ, Kim K, Kwon IC, Chem. Soc. Rev., 41, 2656 (2012)

[7] Lee JE, Lee N, Kim H, Kim J, Choi SH, Kim JH, Kim T, Song IC, Park SP, Moon WK, Hyeon T, J. Am. Chem. Soc., 132(2), 552 (2010)

[8] Park J, An KJ, Hwang YS, Park JG, Noh HJ, Kim JY, Park JH, Hwang NM, Hyeon T, Nat. Mater., 3(12), 891 (2004)

[9] Worden M, Bruckman MA, Kim MH, Steinmetz NF, Kikkawa JM, LaSpina C, Hegmann T, J. Mater. Chem. B, 3, 6877 (2015)

[10] Guerrero-Martinez A, Perez-Juste J, Liz-Marzan LM, Adv. Mater., 22(11), 1182 (2010)

[11] Na HB, Lee JH, An K, et al., Angew. Chem.-Int. Edit., 46, 5397 (2007)

[12] Mueller PS, Parker CP, Larsen SC, Microporous Mesoporous Mater., 204, 173 (2015)

[13] Li XQ, Zhou LP, Gao J, Miao H, Zhang H, Xu J, Powder Technol., 190(3), 324 (2009)

[14] Kao KC, Lin CH, Chen TY, Liu YH, Mou CY, J. Am. Chem. Soc., 137(11), 3779 (2015)

[15] Kim T, Momin E, Choi J, Yuan K, Zaidi H, Kim J, Park M, Lee N, McMahon MT, Quinones-Hinojosa A, Bulte JWM, Hyeon T, Gilad AA, J. Am. Chem. Soc., 133(9), 2955 (2011)

[16] Lang N, Tuel A, Chem. Mater., 16, 1961 (2004)

[17] Fan J, Yu C, Gao T, Lei J, Tian B, Wang L, Luo Q, Tu B, Zhou W, Zhao D, Angew. Chem.-Int. Edit., 42, 3146 (2003)