화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.30, No.3, 212-221, March, 2022
DOI10.1007/s13233-022-0017-9  Export Citation
Cod Gelatin as an Alternative to Cod Collagen in Hybrid Materials for Regenerative Medicine
Victoria Chasova, Ludmila Semenycheva, Marfa Egorikhina1, Irina Charykova1, Daria Linkova1, Yulia Rubtsova, Diana Fukina, Andrey Koryagin, Natalia Valetova, and Evgeny Suleimanov
  • Lobachevsky State University of Nizhny Novgorod, pr. Gagarina 23, 603950 Nizhny Novgorod, Russian Federation
  • 1Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical, University, the Ministry of Health of the Russian Federation (FSBEI HE PRMU MOH), Minin and Pozharsky, Square 10/1, 603950 Nizhny Novgorod, Russian Federation
Collagen and gelatin isolated from the integumentary tissues of cod are almost identical in ash content, molecular weight, but significantly differ in dynamic viscosity. The chemical properties of proteins are studied by the example of catalytic processes: enzymatic hydrolysis and its functional properties in hybrid hydrogel scaffolds in a composition with fibrinogen (Fn), as well as photocatalytic synthesis and the properties of their graft copolymers with polymethyl methacrylate (PMMA). Proteolysis of proteins in an aqueous solution leads to the destruction of peptides mainly with Mn∼10%. Unlike collagen, in the case of gelatin, part of the initial high-molecular macromolecules is not destroyed. In hybrid hydrogel scaffolds in the composition with fibrinogen, cod collagen (CC) is more promising, showing less cytotoxicity in comparison with gelatin. Photocatalytic grafting of methyl methacrylate (MMA) on cod collagen and gelatin (CG) (∼13–15%) with the formation of a graft copolymer PMMA-CG is more effective with collagen. Visualization of the microstructure of a freeze-dried graft copolymer is typical for scaffolds.
Keywords:scaffold;cod collagen;cod gelatin;RbTe1.5W0.5O6 oxide;grafting copolymerization
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