화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.109, 210-220, May, 2022
DOI10.1016/j.jiec.2022.02.004  Export Citation
Development of stimuli-responsive chitosan based hydrogels with anticancer efficacy, enhanced antibacterial characteristics, and applications for controlled release of benzocaine
Muhammad Asim Raza1, 2, Nafisa Gull3, Se-Won Lee4, Kamala-Kannan Seralathan4, and Sang Hyun Park1, 2, †
  • 1Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea
  • 2Radiation Science and Technology, University of Science and Technology, Daejeon 34113, Republic of Korea
  • 3Institute of Polymer and Textile Engineering, University of the Punjab, Lahore 54590, Pakistan
  • 4Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan, Jeonbuk 54596, Republic of Korea
E-mail:
In this work, chitosan and poly(vinylpyrrolidone) based (3-mercaptopropyl)trimethoxysilane (MPTMS) crosslinked hydrogels were prepared for application in drug delivery systems. The swelling behavior in distilled water started to increase until the crosslinker concentration reached the optimum level. The most significant swelling characteristic is noticed in buffer solutions, with higher swelling in an acidic medium and lower swelling in a neutral or basic medium. Morphological studies showed the porous and network structure of specimens, which determines the swelling and release characteristics. Hydrogels manifested antimicrobial characteristics against Listeria monocytogenes (L. monocytogenes) and Salmonella typhimurium (S. typhimurium) bacterial strains. The cell viability against RAW 264.7 cell lines was >90%, and at higher concentrations, the hydrogels showed anti-cancer efficacy against stomach cancerous AGS cell lines. In vitro drug release analysis of benzocaine in phosphate buffer saline (pH 7.4) and simulated intestinal fluid (pH 6.8) showed >90% release within 2 h. These stimuli-responsive hydrogels show enhanced antimicrobial characteristics, biocompatibility, and anti-cancer efficacy, as well as capability of drug release in a controlled manner, which makes them remarkable candidates for use in sustainable drug delivery systems.
Keywords:Chitosan;Poly(vinylpyrrolidone);Swelling;Antimicrobial properties;Drug release
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