Wound healing is a dynamic and complicated process that needs a favorable environment to facilitate healing. Although gauze, lint, plasters, bandages (natural or synthetic), and cotton wool used as primary or secondary dressings to protect the wound from contamination, they have several deficiencies. Thus, modern wound dressings have been designed by the use of natural and synthetic polymers that contribute to wound healing rather than merely covering it. These dressings such as hydrogels, films, and foams are designed to prevent dehydration, control infection and inflammation, and enhance wound healing. In this review article, different natural and synthetic polymers for the preparation of these wound dressings, including hydrogel, film, foam, and smart ones have been discussed. Moreover, the use of natural compounds such as honey and oleoresin for wound healing has been investigated. Hopefully, this review will provide a helpful perspective for future research.