Sea sand vanadia-titania magnetite is difficult to pelletize, and it is difficult for iron and steel enterprises to use it as a raw material for ironmaking. In this paper, the high-temperature physicochemical characteristics and sintering behavior of sea sand vanadia-titania magnetite were comprehensively studied and systematically evaluated. The high-temperature metallurgical physicochemical characteristics of different iron ore powders and under different experimental conditions were studied by the micro-sintering experimental system. The high-temperature sintering indexes were comprehensively evaluated by the grey correlation analysis, and the influence of sea sand ore on sintering performance was investigated by sintering pot experiment. The research results show that the high-temperature sintering characteristics of sea sand vanadia-titania magnetite were the worst, and the grey correlation degree was the lowest. The high-temperature sintering characteristics of sintered blocks with sea sand ore were affected by changing the basicity and the addition amount of sea sand ore. When the basicity was 0.8 and the addition amount of sea sand ore was 15 wt%, the evaluation index of grey relational analysis was the best. The vertical sintering speed and tumble index were slightly reduced by adding sea sand ore, but the sinter yield was improved and the particle size distribution of sinter was optimized. The experimental results provide a certain data reference for the actual production of sinter with sea sand vanadia-titania magnetite.