This work presents a preliminary investigation of Trichoderma reesei (RUT-C30) grown on municipal solid waste (MSW). Such a process offers the potential for inexpensive production of cellulase enzymes while reducing the waste stream to landfills. Cellulase enzyme activity for batch-culture growth on MSW compared favorably with growth on refined cellulosic substrates. Cellulase productivity in an initial fed-batch culture reached a maximum of 22 IFPU/L-h with a maximum activity of 1.5 IFPU/mL.