Journal of Vacuum Science & Technology B, Vol.12, No.3, 1490-1493, 1994
Scanning-Tunneling-Microscopy of Proteins of the Immunoglobulin Super Family
Three different members of the immunoglobulin super-family have been studied. An antibody molecule, prototype of the family, directed against Thy-1, another member of the family, was seen as a V shaped structure, as expected. The corresponding antigen, Thy-1, was imaged at different resolutions. Then, the complex of the two molecules was analyzed and distinctive structures corresponding to each of the two partners were observed. The third member of the family, CD4, was seen as a string of four beads, linearly disposed. Further work needed to draw more detailed conclusions on this family is in progress.