We prepared thioacetate derivatives of C-60 for studying tip-substrate interactions in farce microscopy. They are expected to make ideal hydrophobic surfaces over tips that are covered with thin gold films, Compound (1) has two attaching points by short chain to minimize damping of forces that is expected to be distinct in the case of long chain molecules, while compound (2) is only one attaching point with a long chain. Adsorption kinetics studies by microgravimetry using a quartz crystal microbalance and by contact angle measurements were performed to confirm chemisorption of the prepared compounds. Topographic images of highly oriented pyrolytic graphite attained using tips coated with these compounds do not show deterioration in resolution compared with images obtained using bare tips. On comparing force-distance curves, compound (2) showed a possibility to be advantageous for force measurement experiments because surfaces covered with compound (2)were found to be more hydrophobic than others.