Interfacial Lifshitz-van der Waals theory and acid-base interaction theory of van Oss, Good, and coworkers are applied to the interactions across water-substituted aromatics interfaces. The calculated results agree well with the results obtained from mercury-alkane, mercury-aromatic, water-alkane, and water-aromatic interfacial tension data. The applied methodology allows one to make a quantitative distinction between different kinds of interfacial forces such as Lifshitz-van der Waals and acid-base interactions. The interpretation of the results expressed as work of adhesion components helps to improve the understanding of the interactions and agrees well with the earlier theories of organic chemistry. The electron donor-acceptor capacities of substituted aromatics with water and the population of interacting molecules per unit interfacial area (qualitatively estimated from the molar volume) are the major sources allowing determination of their interfacial tensions and the total work of adhesion between interacting immiscible liquids.