A novel method for determination of the three-phase contact angle at the surface of a micrometer-sized particle (latex sphere, oil droplet, or biological cell) is described. The particle is entrapped within a liquid film of equilibrium thickness smaller than the particle diameter. Thus a liquid meniscus (a layer of uneven thickness) is formed around the particle. When observed in reflected monochromatic light, this meniscus appears as an interference pattern of concentric bright and dark fringes. From the radii of the interference fringes, one can restore the meniscus shape by using the solution of the Laplace equation of capillarity. In this way the three-phase contact angle of the particle and the capillary pressure can be determined. We demonstrate the applicability of our method to latex spheres from several batch samples (between 1 and 7 mu m in diameter) and to oil droplets, stabilized by adsorbed protein layer. The numerical procedures used for contact angle determination are described, and illustrative results are presented and discussed.