In order to improve the yield of isopropanol, we used a new type of zeolite beta catalysts, By using acid-exchange and steaming treatments, various types and contents of binder, different forming and exchanging conditions, we have studied the technological conditions for preparing zeolite beta. As a result, we obtained a new kind of catalyst, Using XRD, SEM, LR, TPD, AAS, etc., we studied the effects of structure and acidity changes of modified zeolite beta on the reaction. The catalytic performance under industrial production conditions was studied. The IPA yield was from 9% to 10%, better than the value of 4% of the original industrial catalyst. Under these circumstances, we scaled the experiment up at the Jinzhou Petrochemical Company and achieved good results, opening up new industrial perspectives.