Applied Catalysis A: General, Vol.143, No.2, 309-316, 1996
Hydrogenation of Pyrrole Derivatives .1. Hydrogenations over Palladium
The heterogeneous catalytic hydrogenation of 1-methyl-2-pyrrole ethanol resulted in 1-methyl-2-pyrrolidine ethanol, an important and valuable pharmaceutical intermediate. In non-acidic medium, with carbon supported palladium catalyst, applying solvent mixtures and mild reaction conditions (6 bar, 80 degrees C) high conversion and selectivity were obtained. This hydrogenation is part of a newly developed and industrially feasible synthesis.