A liquid-solid circulating fluidized-bed (LSCFB) ion-exchange system was developed for continuous protein recovery. It contains a downcomer for protein adsorption and a riser for protein desorption, with ion-exchange particles circulating continuously between the two columns. Effects of the operating conditions oil the hydrodynamics and the continuous ion exchange of bovine serum albumin (BSA) in the system were investigated. Under typical operating conditions, lip to 98% BSA was adsorbed in the downcomer (showing a very high efficiency of protein removal from the feed), and an overall protein recovery of up to 84% was obtained in the LSCFB system, indicating that the LSCFB system was a very promising strategy for the continuous recovery of proteins.