Crystal structures have been determined by X-ray diffraction method for the host-guest complexes with cis-1,4-diphenylcyclohexane-1, 4-diol as the host molecule. The guest molecules are methanol, cis-2-betene-1, 4-diol, trans-2-betene-1, 4-diol, and trans-cyclohexane-1, 4-diol in complexes 1 to 4, respectively. The host-guest interaction in these crystals are based on the hydrogen bond network between the hydroxyl groups of each component molecule. In these crystal structures, hydroxyl group behaves multifunctionally to form the diverse mode of host-guest interactions in these complexes.