Despite growing interest in temporal aspects of auditory neural processing(1,2), little is known about large-scale timing patterns of brain activity during the perception of auditory sequences(3). This is partly because it has not been possible ro distinguish stimulus-related activity from other, endogenous brain signals recorded by electrical or magnetic sensors. Here we use amplitude modulation of unfamiliar, unfamiliar, similar to 1-minute-long tone sequences to label stimulus-related magnetoencephalographic neural activity in human subjects(4-9). We show that temporal patterns of activity recorded over particular brain regions track the pitch contour of tone sequences, with the accuracy of tracking increasing as tone sequences become more predictable in structure. In contrast, temporal synchronization between recording locations, particularly between sites over the left posterior hemisphere and the rest of the brain, is greatest when sequences have melody-like statistical properties(10,11) which may reflect the perceptual integration of local ant; global pitch patterns in melody-like sequences(12). This method is particularly well suited to studying temporal neural correlates of complex auditory sequences (such as speech or music) which engage multiple brain areas as perception unfolds in time.