Novel types of fumaramate bearing a phosphorylcholine group, alkyl-2-[2’-(trimethylammonium)ethyl phosphoryl]ethyl fumaramate [alkyl = isopropyl (IPTPFA) and methyl (MTPFA)] were synthesized, IPTPFA and MTPFA were polymerized and copolymerized with methyl methacrylate (MMA) in the presence of radical initiators. Critical micelle concentrations (CMC) of IPTPFA and MTPFA were 1.7 x 10(-3) and 1.0 x 10(-3) mol l(-1), respectively. Three types of copolymer microspheres of MMA with comonomers such as IPTPFA, MTPFA and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared from the emulsifier-free emulsion copolymerizations over the CMC. An addition of small amounts of IPTPFA or MTPFA resulted in an increase of the rate of polymerization of MMA. Amount of bovine serum albumin adsorption decreased in the following order : poly(MMA) > poly(MTPFA-co-MMA) > poly(IPTPFA-co-MMA) = poly(MPC-co-MMA) microspheres.