Applied Microbiology and Biotechnology, Vol.43, No.6, 1096-1098, 1995
Effect of Amino-Acids on Rapamycin Biosynthesis by Streptomyces-Hygroscopicus
In a chemically defined medium containing aspartate, arginine and histidine to support good growth, addition of L-lysine stimulated rapamycin production by 150%. This was probably due to its conversion to pipecolic acid, a rapamycin precursor. Phenylalanine and methionine interfered in rapamycin production by unknown mechanisms.