Biocompatible and potentially biodegradable polyamides (PAs) containing in the chain both peptide bonds and hydrophilic triethyleneoxide segments have been prepared by interfacial polycondensation of sebacoyl dichloride with amide-diamines derived from the 4,7,10-trioxa-1,13-tridecanediamine and alpha-aminoacids such as glycine, L-valine and L-phenylalanine. These PAs exhibit moderate inherent viscosity values and show limited solubilities in CHCl3, DMF and DMSO. H-1-NMR and FTIR spectroscopy analysis confirmed the expected structures. DSC and X-rays diffraction spectra indicated crystallinity degrees from 19 to 31%. The melting temperatures range between 135-238 degrees C. Liquid water absorption measurements indicate a high equilibrium weight-uptake when a glycine residue is present in the amide-diamine moiety. In vitro tests carried out using cultures of human fibroblasts showed the biocompatibility of the prepared PAs.