In today’s blow molding of complex parts, an optimal resin distribution is critical to a successful operation. These goals are mostly attained through a technique known as parison programming. The process involves varying the die gap during extrusion and therefore results in a parison having a variable thickness along its length. The subsequent inflation of a variable thickness parison is a complex phenomenon involving the interaction of many process variables. The final thickness distribution and inflation patterns were obtained for various programmed parisons. Constant, one step, two step, and sinusoidal thickness parisons were studied. The inflation patterns were monitored by employing a transparent mold in conjunction with a video camera. The experimental data indicated the presence of an oscillatory inflation pattern for some of the variable thickness parisons. The experimental final part thickness distribution for these cases was highly nonlinear. Theoretical predictions of the final thickness distribution were also obtained for some of the cases. The simulation is based on the inflation of a Mooney-Rivlin hyperelastic material. A wide range of deformation is accounted for by introducing an evolutionary Mooney constant, dependent on the level of deformation.