The effects of the injection-molding induced skin-core morphology on the fracture behavior of rubber-toughened polypropylene (RTPP) systems were studied by employing the essential work of fracture (EWF) method. RTPP with 31 wt% ethylene/propylene rubber (EPR) showed no skin-core structure after molding and the EWF approach worked well in this case. In contrast, RTPP with 10 wt% EPR exhibited a pronounced skin-core morphology: EPR depletion and enrichment was observed in the skin and core region, respectively. This morphology caused necking instead of crack growth in deeply double edge-notched (DDENT) specimens under tensile loading along the mold filling direction (MFD). The necking process not only was accompanied by a large scatter but also yielded highly unrealistic specific essential work of fracture (w(e)) values. This skin-core structure was also the reason for an anistropic EWF response of this system observed by loading the specimens both in longitudinal (L) and transverse (T) directions to the MFD. The failure sequence and its characteristics were studied by light microscopy (LM) and infared thermography (IT). It was concluded that the EWF approach cannot be applied for RTPP with a prominent skin-core structure. Since yielding preceded the limited crack growth prior to necking in the loading direction for the DDEN-T specimen of RTPP with 10 wt% EPR the yielding-related specific essential work (w(e,y)) was used for toughness comparison. In case of RTPP with 31 wt% EPR, where yielding was less pronounced prior to the crack growth, the work of fracture until the maximum load was assigned to the yielding-related work of fracture (w(f,y)) used for computing w(e,y). The latter value seems to be closely matched to the plane-strain essential work of fracture value.