Fluorinated materials developed to replace materials banned from manufacture under the Montreal Protocol are themselves contributors to environment damage. In particular, their contribution go global warming is under scrutiny from customers, regulators and pressure groups. This paper provides a comparison of the global warming and other impacts associated with two possible replacements for Halon 1301 (a banned fire extinguishant), namely an ＇in-kind＇ compound CF3CHFCF3 (HFC-227ea) and a ＇not-in-kind＇ blend of nitrogen, argon and carbon dioxide (IG-541). The impacts associated with the manufacture and deployment of the HFC-227ea are found to be substantially greater than those of the inert gas mixture designed for the same fire-extinguishing duty. The impacts during manufacture reveal an important issue for the widely used measure of global warming impact-the so-called Total Equivalent Warming Impact (TEWI). The present work clearly reveals that where impacts associated with manufacture are significant, the scope of the TEWI analysis needs to cover the manufacturing process if it is to be meaningful.