Major Susceptibility Locus for Prostate-Cancer on Chromosome-1 Suggested by a Genome-Wide Search

Smith JR; Freije D; Carpten JD; Gronberg H; Xu JF; Isaacs SD; Brownstein MJ; Bova GS; Guo H; Bujnovszky P; Nusskern DR; Damber JE; Bergh A; Emanuelsson M; Kallioniemi OP; Walkerdaniels J; Baileywilson JE; Beaty TH; Meyers DA; Walsh PC; Collins FS; Trent JM; Isaacs WB

Science, Vol.274, No.5291, 1371-1374, 1996

DOI10.1126/science.274.5291.1371 Export Citation

Major Susceptibility Locus for Prostate-Cancer on Chromosome-1 Suggested by a Genome-Wide Search

Smith JR, Freije D, Carpten JD, Gronberg H, Xu JF, Isaacs SD, Brownstein MJ, Bova GS, Guo H, Bujnovszky P, Nusskern DR, Damber JE, Bergh A, Emanuelsson M, Kallioniemi OP, Walkerdaniels J, Baileywilson JE, Beaty TH, Meyers DA, Walsh PC, Collins FS, Trent JM, Isaacs WB

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

Keywords:INHERITANCE