A nonequilibrium stage model is used to predict composition profiles for binary and multicomponent distillation in a column of spheres and cylinders with a known interfacial area. The profiles generated by the model are compared with experimental data for the binary systems methanol-isopropanol, methanol-water, and isopropanol-water, and for the ternary systems methanol-isopropanol-water and acetone-n-hexane-cyclohexane. The model predicts with a high accuracy the experimental data with an average deviation lower than 1 mol%.