The nuclear fuel reprocessing currently used generates liquid wastes with a significant level of radioactivity that requires expensive and specific treatments. Therefore, in this study, an attempt has been made to develop another process that is more effective and produces less-active wastes by using a poly(4-vinylpyridine) resin as selective material for fixation of metal ions present at trace level, in particular of nonactive ruthenium and, Ru-106, Nb-95, Sb-125, (144)(Ce + Pr), Am-241, Pu, Cm-244.