The major boron minerals, colemanite and ulexite, are frequently found together in boron deposits. Similarities in their chemical compositions create problems in the selective flotation of these minerals, The surface properties of the above boron minerals have been determined by solubility, microflotation, and zeta potential measurements using typical anionic and cationic surfactants. The isoelectric point (iep) of colemanite is 10.5, while ulexite exhibits no iep in a practical pH, Anionic surfactants thus easily float colemanite but fail to float ulexite at a natural pH, This knowledge is used to find the optimum conditions for the selective separation of colemanite from ulexite at a natural pH of 9.3. Cationic surfactants work-well but are adversely affected by the presence of clay-type minerals in the boron ore which hinder the floatability of berates by the formation of a slime coating, The mechanism of slime coating onto boron minerals is also elucidated.