This is a report on the separation and recovery of Cu(II) and Mo(VI) ions from two Chilean mine waters using two hollow fiber-type microporous liquid membrane extraction systems. LIX-860 (a salicylaldoxime) and Alamine 336 (a long-chain tertiary amine) were used as carrier extractants for copper and molybdenum, respectively. The measurements of the permeation of these metallic ions through the liquid membrane indicate that the selective transport of Cu(Il) produced in respect to iron, arsenic, and aluminum in the experiments resulted from a sulfuric acid leach residual solution. The copper permeation is enhanced at pH 7.8 and when the concentration of LIX-860 in the organic phase was increased. Molybdenum and rhenium were efficiently separated from copper and iron metals, which were obtained from a nitric acid leach residual solution, by a liquid membrane prepared using Alamine 336 as the carrier compound. The membrane extractor consisted of two coupled reactors tone for extraction and one for stripping). Circulation of the organic solution between the modules gave a quite good performance for the extraction step and a deficient behavior in the stripping stage. This problem was resolved by using an extraction system which operates with only one module and by impregnating the pores of the hollow fibers used as the solid support with the organic solution. The feed and strip solutions are circulated on opposite sides of the fibers. The experimental results indicated the feasibility of separation and recovery of metals from diluted mine waters by using this membrane technology.