The paper describes the production and immobilization of Langmuir monolayers of recombinant proteins A and G and the chimeric protein A/G. The films were used for the immobilization of IgG molecules on the solid supports. Making use of the high affinity of the proteins A and G to the Fc fragments, the orientation technique provides the IgG position with the Fab fragments nts directed outward, capturing the antigen in the mobile phase. The films of binding receptors were characterized by ellipsometry and nanogravimetry and its IgG binding capacities were tested by fluorescent assays, The immunological activity of IgG alms organized by means of receptor sublayers was studied by the microgravimetric technique. The sensitivity of the monolayer of rabbit anti-mouse IgG oriented with protein A sublayer towards mouse IgG is in the range of 10-100 pM.