Flat sheet membranes made of polyetheretherketone, known as PEEK-WC, and O-octyloxycarbonyl beta-cyclodextrins were prepared by the phase inversion method. The cyclodextrins were entrapped in the polymeric membranes easily and simply in a single operation. Such functionalized membranes were tested for their catalytic activity. PNPA hydrolysis in a cyclodextrin membrane reactor was carried out as a model reaction. A significant improvement of reaction rate in comparison with the batch hydroxide ions catalyzed reaction was observed.