In this paper we discuss the formulation of the governing equations that describe flow of fluids in porous media. Various types of fluid flow, ranging from single-phase flow to compositional flow, are considered. It is shown that all the differential equations governing these types of flow can be effectively rewritten in a fractional flow formulation; i.e., in terms of a global pressure and saturation (or saturations), and that mixed finite element methods can be accurately exploited to solve the pressure equation. Numerical results are presented to see the performance of the mixed methods for the flow equations in three space dimensions.