Turkish Journal of Chemistry, Vol.23, No.2, 123-126, 1999
Transition metal compound mediated reduction of alpha-amino acids to 1,2-amino alcohols with NaBH4 in water
A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH4 in the presence of NiCl2 or MoO3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.
Keywords:O-ALKYL ETHERS;SODIUM-BOROHYDRIDE;ENANTIOSELECTIVE REDUCTION;ASYMMETRIC-SYNTHESIS;SALT SYSTEMS;HYDROGENATION;DERIVATIVES;CONVENIENT;CHLORIDE;KETONES