방사선 가교에 의한 PVA/PVP 하이드로겔 제조 및 드레싱에의 응용

김태훈; 노영창; Tae-Hoon Kim; Young-Chang Nho

Polymer(Korea), Vol.25, No.2, 270-278, March, 2001

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방사선 가교에 의한 PVA/PVP 하이드로겔 제조 및 드레싱에의 응용

Synthesis of PVA/PVP Hydrogel by Irradiation Crosslinking

김태훈, 노영창^†

한국원자력연구소 동위원소ㆍ방사선 응용연구팀

Tae-Hoon Kim, and Young-Chang Nho^†

RadioisotopesㆍRadiation Application Team, Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Taejon 305-600, Korea

E-mail:

초록

의료용 고분자로 널리 알려진 poly(vinylalcohol)(PVA)와 poly(N-vinylpyrrolidone)(PVP)를 이용하여 상처치료용 하이드로겔을 제조하였다. PVP 하이드로겔의 기계적 강도를 향상시키기 위해 PVA/PVP 혼합용액에 "freezing and thawing(동결융해)"을 반복한 후 방사선(⁶⁰Co γ-rays)을 조사하여 하이드로겔을 얻었다. PVA와 PVP의 조성비(30:70∼100:0), 동결융해의 반복횟수, PVA 분자량을 변화시키면서 PVA/PVP 하이드로겔의 겔화율, 팽윤도, 겔강도를 측정하였다. PVA/PVP 하이드로겔은 방사선 조사로만 제조되었을 때 보다 동결융해 반복 후 방사선 조사했을 때 겔화율과 겔강도가 향상되었다. 이외에 동결융해의 반복정도에 따른 물성의 특징을 논의하였다.

Hydrogels for wound dressing were manufactured using poly(vinylalcohol) (PVA) and poly( N-vinylpyrrolidone)(PVP). The hydrogels were obtained by exposing to (60)Co γ-rays after freezing and thawing of aqueous solutions of PVA and PVP to improve mechanical strength. Mechanical properties such as gelation, water absorptivity and gel strength were examined after repeating the "freezing and thawing" of PVA/PVP hydrogels, and then irradiating them at 40 kGy. The PVA:PVP ratio was in the range of 30:70 similar to 1000, and the solid concentration of PVA/PVP was 20 wt%. The gelation and strength of hydrogels were much higher when "freezing and thawing" and the irradiation process were used than when only the irradiation process was utilized. In addition, the mechanical properties of PVA/PVP hydrogels after repetition of "freezing and thawing" are discussed.

Keywords:hydrogels;(60)Co γ-rays;freezing and thawing;PVA;PVP

[References]

Lee JH, Cho YS, Kim HH, Lee JS, Biomaterials Res., 2(4), 180 (1998)
Rosiak JM, J. Control. Release, 31, 9 (1994)
Ilmain F, Tanaka T, Kokufuta E, Nature, 349, 400 (1991)
Rosiak JM, Ulanski P, Rzeznicki A, Nucl. Instr. Meth. Phys. Res., B105, 335 (1995)
Chnh HS, Park H, Kelly P, Robinson JR, J. Pharm. Sci., 74(4), 399 (1985)
Yoshii F, Zhashan Y, Esobe K, Shinozaki K, Makuuchi K, Radiat. Phys. Chem., 55, 133 (1999)
Razzak MT, Zainuddin, Erizal S, Dewi P, Lely H, Taty E, Sukirno, Radiat. Phys. Chem., 55, 153 (1999)
Rosiak JM, Ulanski P, Pajewski LA, Yoshii F, Makuuchi K, Radiat. Phys. Chem., 46(2), 161 (1995)
Singh DK, Ray AR, J. Appl. Polym. Sci., 66(5), 869 (1997)
Hassan CM, Ward JH, Peppas NA, Polymer, 41(18), 6729 (2000)
Mark HF, Gaylod NG, "Encyclopedia of Polymer Science and Technology", vol. 14, p. 398, John Wiley and Sons (1971)
Tranquilan C, Yoshii F, Dela Rosa AM, Makuuchi K, Radiat. Phys. Chem., 55, 127 (1999)
Miranda LF, Lugao AB, Machado LDB, Ramanathan LV, Radiat. Phys. Chem., 55, 709 (1999)

[Referenced By]

[1] Lee JH, Cho YS, Kim HH, Lee JS, Biomaterials Res., 2(4), 180 (1998)

[2] Rosiak JM, J. Control. Release, 31, 9 (1994)

[3] Ilmain F, Tanaka T, Kokufuta E, Nature, 349, 400 (1991)

[4] Rosiak JM, Ulanski P, Rzeznicki A, Nucl. Instr. Meth. Phys. Res., B105, 335 (1995)

[5] Chnh HS, Park H, Kelly P, Robinson JR, J. Pharm. Sci., 74(4), 399 (1985)

[6] Yoshii F, Zhashan Y, Esobe K, Shinozaki K, Makuuchi K, Radiat. Phys. Chem., 55, 133 (1999)

[7] Razzak MT, Zainuddin, Erizal S, Dewi P, Lely H, Taty E, Sukirno, Radiat. Phys. Chem., 55, 153 (1999)

[8] Rosiak JM, Ulanski P, Pajewski LA, Yoshii F, Makuuchi K, Radiat. Phys. Chem., 46(2), 161 (1995)

[9] Singh DK, Ray AR, J. Appl. Polym. Sci., 66(5), 869 (1997)

[10] Hassan CM, Ward JH, Peppas NA, Polymer, 41(18), 6729 (2000)

[11] Mark HF, Gaylod NG, "Encyclopedia of Polymer Science and Technology", vol. 14, p. 398, John Wiley and Sons (1971)

[12] Tranquilan C, Yoshii F, Dela Rosa AM, Makuuchi K, Radiat. Phys. Chem., 55, 127 (1999)

[13] Miranda LF, Lugao AB, Machado LDB, Ramanathan LV, Radiat. Phys. Chem., 55, 709 (1999)