An alternative utilization of virgin grape marc (VGM) to produce SCP from S. cerevisiae is reported. A simple extraction method of fresh grape marc produces a sugar-rich solution; through fed-batch fermentation, a high-value yeast biomass instead of a low-value product like ethanol can be produced. Productivity and quality of yeast are similar to these obtainable from molasses. The convenience of yeast production from VGM is briefly discussed; it appears of great interest in south Italy and generally in grape-producing countries, specially if these lack relevant sources of fermentable sugars. (C) 2001 Elsevier Science Ltd. All rights reserved.